Scaffolds for Meniscus Replacement

Objective

  • Create a bioactive scaffold system that can be customized to fit the patient’s anatomy
  • Scaffolds with angiogenesis functionality at desired locations
  • Incorporate the ability to selectively add cell-matrix biomolecules to control cell growth and differentiation
  • 3D printable using UV light

Impact

  • Ability to precisely control the population of growth factors for enhanced biocompatibility, implant viability, and tissue characteristics
  • Ability to use medical imaging to 3D print scaffolds for customized replacement meniscus tissue

Key Milestones

  • Modify polymer to enable functionalization of scaffolds
  • Design polymer microstructure to obtain optimal biodegradability
  • Optimize pore size of the scaffolds for bio molecule anchoring
  • Confirm angiogenesis properties in animal study with VEGF
  • Complete 3D printable modification strategy
  • Determine economic and commercial viability